Prothena Corp PLC IE00B91XRN20 56,94 82,00 67,58 43,98 363,74Prothena Corp PLC IE00B91XRN20 56,94 82,00 67,58 43,98 363,74Expres2ion Biotech Holding AB SE0008348262 45,56 68,00 44,77 42,31 321,44Skinbiotherapeutics PLC GB00BF33H870 58,00 2128,46 63,12 59,39 307,27Vivoryon Therapeutics NV NL00150002Q7 18,98 45,00 19,14 17,08 278,70Valneva SE FR0004056851 21,54 20,57 16,07 12,84 242,05Bicycle Therapeutics PLC US0887861088 57,56 68,50 48,43 34,39 213,75SynAct Pharma AB SE0008241491 123,60 130,00 107,38 89,02 185,78Mabion SA PLMBION00016 70,10 38,00 72,49 65,38 185,13SwedenCare AB SE0015988167 141,90 170,00 141,89 112,87 179,72Eckert & Ziegler DE0005659700 113,50 127,00 123,48 95,88 169,19AddLife AB SE0014401378 324,60 380,00 340,08 257,28 161,60Allergy Therapeutics PLC GB00B02LCQ05 35,25 65,00 35,67 26,97 160,55Pharmanutra SpA IT0005274094 71,20 87,00 67,23 49,65 156,67Ultimovacs ASA NO0010851603 128,00 180,00 130,22 87,80 155,21Futura Medical PLC GB0033278473 35,70 102,11 36,89 38,55 128,06Animalcare Group PLC GB0032350695 351,00 460,00 390,30 314,70 126,08Indivior PLC GB00BRS65X63 244,80 300,00 221,42 166,97 123,50Merus NV NL0011606264 27,40 39,00 26,52 22,87 113,44Nordic Nanovector ASA NO0010597883 29,06 27,25 25,24 23,41 100,84ProQR Therapeutics NV NL0010872495 8,36 21,50 7,79 6,45 93,95Bachem Holding AG CH0012530207 711,00 817,00 741,88 550,61 88,49Oxford Biomedica PLC GB00BDFBVT43 1494,00 1780,00 1506,28 1248,78 88,32Avadel Pharmaceuticals PLC US05337M1045 11,07 17,00 9,13 8,32 86,64Labomar SpA IT0005421646 12,15 10,65 12,80 11,42 86,41Selvita SA PLSLVCR00029 78,70 84,25 76,09 72,65 85,35Virbac SA FR0000031577 410,00 420,00 379,45 299,50 84,66Nanoform Finland Plc FI4000330972 7,15 8,70 7,63 7,27 84,56Biofarm SA ROBIOFACNOR9 0,74 0,68 0,65 0,61 82,64Evotec SE DE0005664809 41,48 40,00 42,08 36,74 73,75Ergomed PLC GB00BN7ZCY67 1540,00 1536,00 1419,10 1267,99 73,71Transgene SA FR0005175080 2,50 4,00 2,47 2,51 70,89Dermapharm Holding SE DE000A2GS5D8 81,25 87,50 84,37 71,76 70,73Circassia Group Plc GB00BJVD3B28 42,10 — 41,59 33,87 70,09Affimed NV NL0010872420 5,69 12,00 6,32 7,35 67,02Laboratorios Farmaceuticos Rovi SA ES0157261019 57,10 68,10 57,33 53,72 66,92Vetoquinol SA FR0004186856 146,60 148,30 137,55 114,44 66,32Biotest AG DE0005227201 43,10 39,60 41,00 33,86 66,28Destiny Pharma PLC GB00BDHSP575 121,50 370,00 115,36 129,03 65,13Synairgen PLC GB00B0381Z20 180,50 747,50 165,30 157,25 63,36Xbrane Biopharma AB SE0007789409 118,20 212,50 132,61 125,05 62,74Bavarian Nordic A/S DK0015998017 307,50 397,50 321,18 278,31 60,73Malin Corp PLC IE00BVGC3741 6,75 9,50 6,77 6,46 60,71Heidelberg Pharma AG DE000A11QVV0 5,88 8,92 5,91 6,90 58,15Hyloris Pharmaceuticals SA BE0974363955 15,70 16,50 14,19 13,40 57,92ArcticZymes Technologies ASA NO0010014632 91,90 132,00 87,63 86,26 57,12Sensorion SA FR0012596468 1,85 4,75 1,95 1,99 55,00Tissue Regenix Group PLC GB00B5SGVL29 0,62 0,52 0,63 0,66 53,66GeNeuro SA CH0308403085 3,80 6,55 3,82 3,77 49,62Advicenne SACA FR0013296746 8,78 25,00 7,71 9,60 49,50AC Immune SA CH0329023102 7,67 16,00 6,73 7,11 48,53Formycon AG DE000A1EWVY8 49,45 78,00 52,06 58,49 47,77Scancell Holdings PLC GB00B63D3314 20,00 23,00 21,59 21,56 47,66Swedish Orphan Biovitrum AB SE0000872095 233,20 235,00 235,88 174,54 47,35Dechra Pharmaceuticals PLC GB0009633180 4834,00 4705,00 4963,76 4360,43 46,97BioArctic AB SE0010323311 129,60 225,00 139,91 116,23 45,90Endo International PLC IE00BJ3V9050 6,25 7,50 3,73 5,39 45,61Krka dd Novo mesto SI0031102120 113,00 133,50 111,77 104,93 43,70PhotoCure ASA NO0010000045 119,40 160,00 113,16 125,75 43,46Myovant Sciences Ltd BMG637AM1024 22,54 25,00 22,32 21,76 43,32Pierrel SpA IT0004007560 0,23 0,32 0,23 0,25 43,03Alkaloid AD Skopje MKALKA101011 16999,59 — 17358,36 15741,62 42,58DBV Technologies SA FR0010417345 5,53 11,65 8,20 9,16 40,68ICON PLC IE0005711209 278,12 315,00 270,63 228,02 38,84Alkermes PLC IE00B56GVS15 25,35 28,50 30,60 24,94 38,64Alliance Pharma PLC GB0031030819 102,60 120,00 104,19 98,02 37,96Siegfried Holding AG CH0014284498 885,00 1000,00 866,18 826,48 37,38Eurofins-Cerep FR0013256518 16000,00 — 15353,85 14466,67 35,59Abivax SA FR0012333284 26,65 55,00 30,19 27,44 35,50ALK-Abello A/S DK0060027142 3028,00 3362,50 2876,44 2789,28 34,86Innate Pharma SA FR0010331421 4,59 6,00 5,11 3,76 33,86AB Science SA FR0010557264 12,65 — 13,16 13,54 31,86Olainfarm AS LV0000100501 9,26 9,26 9,27 8,34 31,37Medincell SA FR0004065605 9,83 16,06 9,17 10,17 30,28GenSight Biologics SA FR0013183985 5,43 15,50 7,22 7,78 30,05BB Biotech AG CH0038389992 80,75 82,21 84,09 84,87 29,78Intervacc AB SE0009607252 59,00 — 64,83 74,38 29,33Genus PLC GB0002074580 5475,00 5723,00 5559,10 5310,47 29,18Argenx SE NL0010832176 270,40 330,00 266,32 258,18 28,34MagForce AG DE000A0HGQF5 3,16 11,00 3,27 3,86 27,42Richter Gedeon Nyrt HU0000123096 8595,00 10105,00 8632,75 8509,59 27,06Silence Therapeutics PLC GB00B9GTXM62 563,00 706,00 533,22 582,51 27,03Valbiotis SAS FR0013254851 6,77 14,00 6,96 7,19 26,87Guerbet FR0000032526 37,15 45,00 39,28 33,58 26,79Sequana Medical NV BE0974340722 7,72 12,00 6,91 8,06 26,30Adocia FR0011184241 8,93 16,50 9,53 9,53 25,53Biovica International AB SE0008613731 41,30 103,00 50,59 46,77 25,52ObsEva SA CH0346177709 2,46 12,50 2,88 3,03 25,51Recordati Industria Chimica e Farmaceuti IT0003828271 55,92 50,15 52,23 48,92 24,78Faron Pharmaceuticals Oy FI4000153309 340,00 480,04 369,90 373,71 24,77MDxHealth SA BE0003844611 1,02 1,20 1,20 1,21 24,28Xlife Sciences AG CH0461929603 46,40 — 47,87 48,95 22,99Abcam PLC GB00B6774699 1688,00 1436,50 1559,80 1485,24 22,44InflaRx NV NL0012661870 4,87 9,50 3,04 3,39 20,88Financiere de Tubize SA BE0003823409 96,50 115,00 90,37 84,86 20,86Almirall SA ES0157097017 12,72 16,00 13,46 13,36 20,53Eurobio Scientific SA FR0013240934 17,00 37,00 17,88 18,92 18,07Vaccibody AS NO0010714785 67,50 67,00 68,91 75,40 18,02PCAS FR0000053514 10,70 — 12,53 13,52 17,37Redx Pharma PLC GB00BSNB6S51 78,50 135,00 85,14 68,10 16,36Benchmark Holdings Plc GB00BGHPT808 64,00 71,00 60,82 59,66 16,20Vistin Pharma ASA NO0010734122 18,48 — 20,00 22,84 15,30Antibiotice SA ROATBIACNOR9 0,57 0,55 0,56 0,54 14,68Ryvu Therapeutics SA PLSELVT00013 62,40 68,20 58,77 56,11 13,90QIAGEN NV NL0012169213 46,39 50,00 45,93 42,94 13,87Iterum Therapeutics plc IE00BF3W0Q35 0,57 1,00 0,58 1,17 12,67Tchaikapharma High Quality Medicines BG1100008074 14,50 — 14,39 14,21 12,40UCB SA BE0003739530 106,45 111,00 97,96 88,05 11,93Nanobiotix SA FR0011341205 8,46 23,50 10,06 12,17 11,93Oryzon Genomics SA ES0167733015 3,09 8,05 3,21 3,55 10,68OSE Immuno FR0012127173 8,72 16,05 10,51 11,15 10,50Eco Animal Health Group PLC GB0032036807 252,50 442,00 305,03 336,00 10,02Egetis Therapeutics AB SE0003815604 6,17 20,00 6,03 6,04 10,00Bioton SA PLBIOTN00029 4,74 — 4,80 5,12 9,45Boiron SA FR0000061129 41,50 44,00 41,29 39,50 9,42Immatics NV NL0015285941 10,84 24,50 13,60 12,24 9,29Inventiva SACA FR0013233012 12,28 23,00 11,86 11,75 8,82MPH Mittelständische Pharma Holding AG DE000A289V03 22,50 75,00 23,33 26,26 7,62Diurnal Group PLC GB00BDB6Q760 59,50 138,00 58,96 63,57 7,21Mithra Pharmaceuticals SA BE0974283153 18,78 33,50 19,35 21,69 7,04Adaptimmune Therapeutics Plc US00653A1079 5,40 8,00 5,39 4,97 5,56Perrigo Co PLC IE00BGH1M568 41,84 59,50 45,00 44,21 5,26HAEMATO AG DE000A289VV1 24,00 50,00 24,33 26,53 3,91Kuros Biosciences AG CH0325814116 2,15 5,00 2,33 2,29 3,90Curasight A/S DK0061295797 21,70 — 25,03 28,30 3,86ReNeuron Group PLC GB00BF5G6K95 104,00 400,00 104,51 113,30 3,67Biocorp FR0012788065 29,10 — 26,55 27,37 3,18Faes Farma SA ES0134950F36 3,48 4,53 3,43 3,47 1,72Ipsen SA FR0010259150 86,46 92,00 84,83 81,79 1,67Orion Oyj FI0009014377 38,48 38,00 35,59 35,67 0,96Amarin Corp PLC US0231112063 4,25 10,00 5,00 5,30 0,48Medigene AG DE000A1X3W00 3,65 8,00 3,70 3,89 -0,27Avacta Group PLC GB00BYYW9G87 108,50 200,00 120,48 177,75 -0,91Vifor Pharma AG CH0364749348 118,90 133,50 123,15 125,54 -0,95Biophytis SA FR0012816825 0,52 1,00 0,64 0,92 -1,42Mereo Biopharma Group PLC US5894921072 2,39 10,00 2,41 3,04 -1,66Compass Pathways Plc US20451W1018 33,45 70,00 34,77 36,74 -2,99OptiBiotix Health PLC GB00BP0RTP38 50,00 — 49,84 50,64 -3,03BioInvent International AB SE0015244520 42,04 92,50 38,77 47,95 -3,41Hikma Pharmaceuticals PLC GB00B0LCW083 2376,50 2880,00 2427,84 2422,63 -4,90H Lundbeck A/S DK0010287234 183,95 230,00 177,29 199,41 -5,69Ascendis Pharma A/S US04351P1012 157,65 193,00 158,93 140,84 -5,71Genfit FR0004163111 3,19 6,30 3,27 3,57 -6,71Irlab Therapeutics AB SE0012675361 48,00 99,40 46,76 44,37 -6,90Clinigen Group Plc GB00B89J2419 588,00 758,17 633,12 698,80 -7,42Zentiva SA ROSCDBACNOR8 2,62 2,84 2,68 2,78 -7,75Quantum Genomics SAS FR0011648971 3,91 14,60 4,70 4,43 -8,28Bioventix PLC GB00B4QVDF07 3625,00 4300,00 3852,50 4042,03 -8,40CRISPR Therapeutics AG CH0334081137 90,09 160,00 106,56 122,27 -8,41Medivir AB SE0000273294 10,30 13,50 10,03 9,06 -8,61Poxel SA FR0012432516 5,75 15,90 6,10 6,47 -8,73COSMO Pharmaceuticals NV NL0011832936 73,70 110,00 76,09 83,78 -8,82Laboratorio Reig Jofre SA ES0165359029 3,78 — 4,32 5,12 -8,86Karo Pharma AB SE0007464888 58,30 60,00 55,53 54,10 -9,69Jazz Pharmaceuticals PLC IE00B4Q5ZN47 138,47 205,00 135,10 159,03 -9,70Oncodesign FR0011766229 9,55 17,50 10,26 11,40 -10,05Vicore Pharma Holding AB SE0007577895 17,14 76,00 19,66 23,13 -11,62Marinomed Biotech AG ATMARINOMED6 99,60 150,00 111,36 121,61 -12,28Centogene NV NL0014040206 9,89 22,00 10,10 10,87 -12,53ADC Therapeutics SA CH0499880968 28,98 44,00 27,26 25,42 -12,66Basilea Pharmaceutica AG CH0011432447 42,04 70,00 44,49 45,98 -12,78Scope Fluidics SA PLSCPFL00018 156,40 — 152,78 141,38 -13,59Sopharma Trading AD/Sofia BG1100086070 4,98 — 4,97 5,36 -14,14Paion AG DE000A0B65S3 1,78 4,00 1,77 1,91 -14,69Open Orphan PLC GB00B9275X97 20,25 44,50 22,23 28,99 -15,63Celon Pharma SA PLCLNPH00015 35,50 56,00 38,18 43,42 -15,91Zealand Pharma A/S DK0060257814 200,00 220,00 199,98 194,33 -16,89Nicox FR0013018124 3,22 12,00 3,37 3,83 -17,592invest AG DE000A3H3L44 13,00 — 12,82 12,24 -17,61Amryt Pharma PLC GB00BKLTQ412 166,50 338,33 171,10 181,98 -17,63uniQure NV NL0010696654 34,75 66,00 32,60 32,41 -17,69Camurus AB SE0007692850 164,00 238,00 171,44 196,91 -19,32Oxurion NV BE0003846632 2,20 3,00 2,06 2,37 -19,41Verona Pharma PLC US9250501064 5,23 18,00 5,26 6,65 -20,71Deutsche Biotech Innovativ AG DE000A0Z25L1 86,00 — 90,28 90,58 -20,95Pharming Group NV NL0010391025 0,82 1,70 0,81 0,97 -21,29Q-Linea AB SE0011527845 112,60 170,00 133,64 146,17 -21,94Yourgene Health PLC GB00BN31ZD89 12,75 20,00 14,44 14,21 -22,50Acacia Pharma Group PLC GB00BYWF9Y76 1,63 6,90 1,97 2,29 -22,75Cassiopea SpA IT0005108359 32,40 65,00 34,45 43,23 -24,32Fagron BE0003874915 14,74 22,50 16,20 18,28 -24,34Addex Therapeutics Ltd CH0029850754 1,22 — 1,39 1,55 -26,04Ascelia Pharma AB SE0010573113 28,15 — 29,15 35,58 -26,27Bergenbio ASA NO0010650013 19,65 55,80 20,89 25,51 -26,43Onxeo SA FR0010095596 0,48 1,00 0,54 0,64 -26,574d pharma plc GB00BJL5BR07 78,40 — 69,10 96,26 -27,60Biofrontera AG DE0006046113 1,98 6,80 2,39 2,60 -28,29PCI Biotech Holding ASA NO0010405640 14,92 37,00 16,24 23,33 -28,60Idorsia Ltd CH0363463438 18,42 30,00 21,07 23,75 -28,64Orexo AB SE0000736415 29,76 115,00 33,40 39,41 -28,69Grifols SA ES0171996087 18,50 27,10 20,64 21,75 -28,73Molecular Partners AG CH0256379097 14,04 23,20 17,99 20,66 -30,00Isofol Medical AB SE0009581051 9,18 23,00 8,96 11,74 -30,88Targovax AS NO0010689326 4,49 12,25 6,36 7,62 -33,33OKYO Pharma Ltd GG00BD3FV870 5,45 — 4,99 6,35 -33,94Evolva Holding SA CH0021218067 0,14 0,25 0,15 0,18 -34,01CureVac NV NL0015436031 36,28 50,00 49,65 77,86 -34,38Venture Life Group Plc GB00BFPM8908 59,50 — 56,84 79,10 -34,88Cellectis SA FR0010425595 9,58 — 10,71 13,68 -35,76BoneSupport Holding AB SE0009858152 39,05 58,00 44,92 63,96 -36,34Oxford BioDynamics PLC GB00BD5H8572 45,00 — 46,58 61,71 -39,60NuCana PLC US67022C1062 2,81 20,00 2,46 3,39 -39,65Immunic Inc US4525EP1011 10,20 57,50 9,06 12,40 -40,31Autolus Therapeutics PLC US05280R1005 6,81 13,00 6,31 6,32 -40,424SC AG DE000A3E5C40 4,64 — 4,72 6,86 -42,74OncoArendi Therapeutics SA PLONCTH00011 39,00 55,55 42,34 47,87 -43,03Infant Bacterial Therapeutics AB SE0008015259 74,70 345,00 78,33 94,71 -44,44Biomed-Lublin Wytwornia Surowic i Szczep PLBMDLB00018 8,25 — 9,50 10,25 -44,53Calliditas Therapeutics AB SE0010441584 79,00 145,00 97,79 116,61 -45,50Pharma Mar SA ES0169501022 61,86 90,25 72,89 83,93 -46,33EXACT Therapeutics AS NO0010852213 16,40 — 19,63 24,23 -46,87Immunicum AB SE0005003654 4,53 9,76 4,08 5,05 -47,00Oasmia Pharmaceutical AB SE0000722365 2,13 6,45 2,38 2,99 -48,93Tiziana Life Sciences Ltd BMG889121031 1,43 7,89 1,60 2,28 -49,15Index Pharmaceuticals Holding AB SE0008966295 1,46 — 1,45 1,58 -49,44Celyad Oncology SA BE0974260896 3,66 7,00 3,78 4,75 -50,26Enzymatica AB SE0003943620 10,02 — 10,39 11,49 -50,30Santhera Pharmaceuticals Holding AG CH0027148649 1,30 — 1,59 2,44 -51,40XSpray Pharma AB SE0009973563 68,80 175,00 104,73 106,81 -51,73DIAMYD MEDICAL AB SE0005162880 16,75 — 24,65 28,56 -52,76Galapagos NV BE0003818359 47,66 55,00 46,51 58,10 -52,94MorphoSys AG DE0006632003 38,36 70,00 41,62 62,19 -55,50Orphazyme A/S DK0060910917 26,20 13,00 28,07 46,31 -57,40Saniona AB SE0005794617 10,04 57,00 13,08 17,69 -58,26Scandion Oncology A/S DK0061031895 13,64 — 16,36 18,03 -61,28Erytech Pharma SA FR0011471135 2,17 4,30 4,57 5,26 -61,49Orchard Therapeutics plc US68570P1012 1,83 11,50 2,31 4,62 -62,15Hansa Biopharma AB SE0002148817 94,18 287,50 113,46 138,05 -62,79Novacyt SA FR0010397232 2,69 6,09 3,39 4,99 -65,40Kancera AB SE0015658570 8,55 — 9,10 12,46 -67,23Shield Therapeutics PLC GB00BYV81293 36,50 260,00 38,99 45,26 -69,89Cantargia AB SE0006371126 15,98 53,50 20,12 29,04 -72,94Galecto Inc US36322Q1076 3,57 14,50 3,70 5,69 -76,90Relief Therapeutics Holding AG CH0100191136 0,05 — 0,12 0,21 -79,44Oncopeptides AB SE0009414576 5,06 6,35 30,72 89,93 -96,68